LINC00452

Across TCGA patient cohorts, LINC00452 mutation is significantly associated with the RNA expression of many other genes, with 835 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LINC00452-associated genes across cancer lineages are ZBTB7A, DCTPP1, and GTF2H2C. Each is linked with LINC00452 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINC00452-to-partner and partner-to-LINC00452 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBTB7A grouped by LINC00452-low versus LINC00452-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINC00452→partner) and Y-score (partner→LINC00452) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZBTB7A →	+0.667	+3.343	<.001	.005	3	1
UCEC	DCTPP1 →	+0.877	+3.332	.001	.005	3	1
UCEC	GTF2H2C →	+0.415	+3.241	.001	.009	3	1
UCEC	VPS33B →	+0.389	+3.343	.007	.005	3	1
UCEC	IRAK1 →	+1.000	+3.354	<.001	.005	3	1
UCEC	SMYD4 →	+0.727	+3.387	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 835 associations by consensus.

ZBTB7A by LINC00452 expression — UCEC

Explore this box plot interactively →