LINC00452

Across TCGA patient cohorts, LINC00452 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LINC00452-associated genes across cancer lineages are 14-3-3_beta, ERK2, and P-Cadherin. Each is linked with LINC00452 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINC00452-to-partner and partner-to-LINC00452 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by LINC00452-low versus LINC00452-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINC00452→partner) and Y-score (partner→LINC00452) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.124	-2.986	.032	.037	3	1
UCEC	ERK2 →	+0.233	+3.000	.036	.037	3	1
UCEC	P-Cadherin →	-0.195	-2.990	.019	.036	3	1
UCEC	PCNA →	+0.308	+3.000	.013	.037	3	1
UCEC	VEGFR2 →	+0.347	+3.013	.043	.019	3	1
UCEC	c-Jun_pS73 →	-0.191	-3.000	.037	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

14-3-3_beta by LINC00452 expression — UCEC

Explore this box plot interactively →