LINC00398

Across TCGA pan-cancer cohorts, LINC00398 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LINC00398’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where LINC00398 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00398 is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

BLCA, UCEC, and LUSC are the cancer types where LINC00398 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00398 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−0.620	.002	6	view →
UCEC	All	II,III,IV	−0.404	<.001	6	view →
LUSC	All	II,III,IV	−0.264	<.001	6	view →
BRCA	All	II,III,IV	−0.281	<.001	4	view →
THCA	All	III,IV	−0.388	.021	3	view →
COAD	All	IV	+0.180	.025	3	view →
PRAD	All	All	−0.421	<.001	2	view →
KIRP	All	All	−0.157	.011	2	view →
CHOL	All	All	−0.180	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LINC00398–BLCA

Open the BLCA breakdown →