Across TCGA pan-cancer cohorts, LINC00383 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of LINC00383’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where LINC00383 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00383 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
BRCA, LIHC, and THCA are the cancer types where LINC00383 tumor–normal differential expression is most reproducible.