Across TCGA pan-cancer cohorts, LINC00381 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of LINC00381’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC00381 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00381 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LUSC, and BLCA are the cancer types where LINC00381 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00381 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.154	.001	8	view →
LUSC	All	All	+0.195	<.001	5	view →
BLCA	All	All	+0.102	.011	5	view →
KICH	All	II,III,IV	−0.088	<.001	4	view →
ESCA	All	II,III,IV	+0.334	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: LINC00381 RNA expression & survival · all LINC00381 data types