long intergenic non-protein coding RNA 378Genealiases: []
Q-omics provides the consensus-scored LINC00378 profile across patient tissues and cancer cell-line models. LINC00378 expression is associated with patient survival in 12 of 34 cancer types, with the highest sampling consensus in CESC. Among the 18 cancer types available for tumor–normal comparison, LINC00378 is differentially expressed in 1, with the highest sampling consensus in BRCA. Additionally, LINC00378 RNA expression shows 10,317 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight CESC, BRCA, and TGCT as cancer lineages where LINC00378 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC00378 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC00378 survival associations across molecular data types. LINC00378 RNA expression shows survival associations in the most cancer types (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC00378 RNA expression–survival associations across cancer types. High LINC00378 expression shows unfavorable associations in CESC, KICH, ACC, ESCA, LUAD and HNSC. The CESC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify CESC as the clearest survival context for LINC00378 RNA expression.
This table summarizes LINC00378 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for LINC00378. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC00378 shows lower tumor expression in BRCA. The BRCA box plot shows higher LINC00378 RNA expression in normal versus tumor tissue (log2 FC = −0.007, t-test p = .025).
This table shows molecular features associated with LINC00378 in patient tissues and cancer cell lines. In patient samples, LINC00378 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
