Q-omics provides the consensus-scored LINC00377 profile across patient tissues and cancer cell-line models. LINC00377 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in BRCA. Among the 18 cancer types available for tumor–normal comparison, LINC00377 is differentially expressed in 10, with the highest sampling consensus in BLCA. Additionally, LINC00377 RNA expression shows 12,530 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight BRCA, BLCA, and UVM as cancer lineages where LINC00377 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC00377 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC00377 survival associations across molecular data types. LINC00377 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC00377 RNA expression–survival associations across cancer types. High LINC00377 expression shows unfavorable associations in UVM, LUAD and KICH, but favorable associations in BRCA, HNSC and KIRP. The BRCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify BRCA as the clearest survival context for LINC00377 RNA expression.
This table summarizes LINC00377 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in BLCA for RNA.
This table ranks reproducible tumor–normal expression differences for LINC00377. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC00377 shows lower tumor expression in BLCA, BRCA, LUSC, KICH, LUAD and STAD. The BLCA box plot shows higher LINC00377 RNA expression in normal versus tumor tissue (log2 FC = −0.485, t-test p < 0.001).
This table shows molecular features associated with LINC00377 in patient tissues and cancer cell lines. In patient samples, LINC00377 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
