Across TCGA pan-cancer cohorts, LINC00358 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC00358’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC00358 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00358 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC and KIRP are the cancer types where LINC00358 tumor–normal differential expression is most reproducible.