Across TCGA pan-cancer cohorts, LINC00331 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LINC00331’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where LINC00331 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00331 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC are the cancer types where LINC00331 tumor–normal differential expression is most reproducible.