Across TCGA pan-cancer cohorts, LINC00266-1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LINC00266-1’s most consistent transcriptional readouts.
The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where LINC00266-1 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00266-1 is over-expressed in tumor, although a few such as PAAD and UCEC show the opposite, repressed pattern.
PAAD, UCEC, and KIRP are the cancer types where LINC00266-1 tumor–normal differential expression is most reproducible.