LINC00261

Across TCGA pan-cancer cohorts, LINC00261 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LINC00261’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LINC00261 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00261 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and LUAD are the cancer types where LINC00261 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00261 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.700	<.001	10	view →
LUSC	Female	II,III,IV	−3.460	<.001	9	view →
LUAD	Female	III,IV	−2.245	<.001	9	view →
LIHC	All	All	−0.854	<.001	7	view →
UCEC	All	All	+2.599	<.001	6	view →
KICH	All	All	−0.036	.001	3	view →
CHOL	All	All	−1.774	.003	2	view →
PRAD	All	All	−1.182	<.001	2	view →
KIRC	Male	All	−0.026	.002	2	view →
STAD	All	IV	−3.166	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LINC00261–THCA

Open the THCA breakdown →