LINC00235

Across TCGA pan-cancer cohorts, LINC00235 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LINC00235’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LINC00235 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00235 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and KICH are the cancer types where LINC00235 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00235 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.877	<.001	11	view →
LIHC	Female	II,III,IV	+0.435	<.001	9	view →
KICH	Male	All	−1.375	<.001	7	view →
COAD	Female	II,III,IV	+0.440	<.001	7	view →
KIRP	All	II,III,IV	+0.899	.004	4	view →
UCEC	All	All	−0.560	<.001	4	view →
CHOL	All	All	+0.947	<.001	3	view →
KIRC	Male	II,III,IV	−0.443	.015	3	view →
HNSC	All	II,III,IV	+0.212	.010	3	view →
BLCA	Male	IV	−0.715	.008	2	view →
LUSC	All	All	+0.233	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

LINC00235–THCA

Open the THCA breakdown →