LINC00174

Across TCGA pan-cancer cohorts, LINC00174 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LINC00174’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC00174 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00174 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where LINC00174 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00174 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.036	<.001	12	view →
KIRC	Male	II,III,IV	+0.442	<.001	11	view →
COAD	All	IV	+0.885	<.001	10	view →
THCA	All	All	−0.435	<.001	8	view →
LUSC	All	All	+0.680	<.001	5	view →
LIHC	All	All	+0.443	<.001	5	view →
STAD	All	II,III,IV	+0.698	.008	4	view →
READ	All	All	+1.250	<.001	3	view →
KIRP	All	IV	+1.172	.022	2	view →
CHOL	All	All	+0.967	.001	2	view →
ESCA	All	II,III,IV	+0.840	.030	2	view →
PRAD	All	All	+0.241	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LINC00174–HNSC

Open the HNSC breakdown →