Across TCGA pan-cancer cohorts, LINC00161 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of LINC00161’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where LINC00161 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00161 is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.
BLCA, HNSC, and KIRC are the cancer types where LINC00161 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00161 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.