Across TCGA patient cohorts, LIN9 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIN9-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and p70-S6K_pT389. Each is linked with LIN9 in more than 2 cancer types. Because this analysis shows association rather than direction, both LIN9-to-partner and partner-to-LIN9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN9→partner) and Y-score (partner→LIN9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.512	+1.604	.007	.010	3	3
UCEC	eIF4E →	+0.190	+3.472	.005	.002	3	2
UCEC	p70-S6K_pT389 →	-0.186	-2.807	.002	.002	3	2
UCEC	Annexin-1 →	+0.609	+2.189	<.001	.001	3	2
UCEC	4E-BP1 →	+0.315	+3.936	<.001	<.001	2	3
UCEC	Cyclin-B1 →	+0.612	+2.700	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

LIN9 survival (RNA) · tumor vs normal (RNA) · all LIN9 data types