Across TCGA cell cohorts, LIN9 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LIN9-associated genes across cancer lineages are OR4F15, URAD, and OR52N4. Each is linked with LIN9 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN9-to-partner and partner-to-LIN9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN9→partner) and Y-score (partner→LIN9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR4F15 →	+0.022	+5.029	<.001	.006	3	1
LUNG_SCLC	URAD →	+0.065	+5.029	<.001	.006	3	1
SKIN	OR52N4 →	+0.202	+4.977	<.001	.007	3	1
BLOOD_Leukemia	RNF17 →	+0.161	+3.807	<.001	.001	3	1
BLOOD_Leukemia	RGR →	+0.019	+3.684	.003	.004	3	1
BLOOD_Leukemia	RPL10L →	+0.037	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

LIN9 survival (RNA) · tumor vs normal (RNA) · all LIN9 data types