LIN7C

Across TCGA pan-cancer cohorts, LIN7C mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LIN7C data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher LIN7C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LIN7C expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and LSCC are the cancer types where LIN7C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	1.000	0.897	.011	72	view →
PDAC	OS	Tertile	All	0.996	0.628	<.001	42	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.460	.002	40	view →
UCEC	DFS	Median	All	0.970	0.744	<.001	22	view →
CCRCC	DFS	Quartile	All	0.676	0.925	.009	17	view →
LUAD	OS	Tertile	All	0.973	0.913	.024	8	view →
GBM	DFS	Quartile	All	0.301	0.616	.011	7	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LIN7C–COAD (DFS)

Open the COAD breakdown →