LIN7C

Across TCGA patient cohorts, LIN7C mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIN7C-associated genes across cancer lineages are ERK2, Fibronectin, and Heregulin. Each is linked with LIN7C in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN7C-to-partner and partner-to-LIN7C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by LIN7C-low versus LIN7C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN7C→partner) and Y-score (partner→LIN7C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.204	+2.222	.012	.011	3	1
UCEC	Fibronectin →	-0.300	-3.156	.032	.018	3	1
UCEC	Heregulin →	-0.131	-2.986	.012	.035	3	1
UCEC	INPP4B →	-0.284	-1.687	.038	.044	3	1
UCEC	NF2 →	+0.318	+2.459	<.001	.018	3	1
UCEC	p62 Lck ligand →	+0.334	+2.179	.015	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ERK2 by LIN7C expression — UCEC

Explore this box plot interactively →