LIN7B

Across TCGA patient cohorts, LIN7B mutation is significantly associated with the RNA expression of many other genes, with 661 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIN7B-associated genes across cancer lineages are RNA5SP412, MBD3L3, and CTAGE15. Each is linked with LIN7B in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN7B-to-partner and partner-to-LIN7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by LIN7B-low versus LIN7B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN7B→partner) and Y-score (partner→LIN7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP412 →	+0.259	+7.930	<.001	.008	3	2
COAD	MBD3L3 →	+0.129	+7.741	<.001	.009	3	1
UCEC	CTAGE15 →	+0.190	+3.541	.007	.003	3	1
UCEC	CCL5 →	+1.691	+3.721	<.001	<.001	3	1
UCEC	MIR98 →	+0.403	+2.953	<.001	.001	3	1
UCEC	H2BC14 →	+0.503	+3.711	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 661 associations by consensus.

RNA5SP412 by LIN7B expression — LUAD

Explore this box plot interactively →