LIN7B

Across TCGA patient cohorts, LIN7B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIN7B-associated genes across cancer lineages are HER3_pY1289, MAPK_pT202_Y204, and p90 RSK. Each is linked with LIN7B in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN7B-to-partner and partner-to-LIN7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by LIN7B-low versus LIN7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN7B→partner) and Y-score (partner→LIN7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.097	+2.827	.040	.035	3	1
UCEC	MAPK_pT202_Y204 →	-0.520	-3.169	.043	.020	3	1
UCEC	p90 RSK →	+0.228	+2.817	.030	.036	2	1
UCEC	Cyclin-E2 →	+0.232	+3.169	.012	.020	2	1
UCEC	EGFR →	-0.214	-3.169	.014	.020	1	1
UCEC	PCNA →	+0.315	+3.169	.007	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

HER3_pY1289 by LIN7B expression — UCEC

Explore this box plot interactively →