LIN7B

Across TCGA cell cohorts, LIN7B mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible LIN7B-associated genes across cancer lineages are SPATA3 and PZP. Each is linked with LIN7B in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN7B-to-partner and partner-to-LIN7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA3 grouped by LIN7B-low versus LIN7B-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN7B→partner) and Y-score (partner→LIN7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SPATA3 →	+0.030	+5.169	<.001	.004	3	1
BLOOD_Myeloma	PZP →	+0.036	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

SPATA3 by LIN7B expression — BONE

Explore this box plot interactively →