LIN7A

Across TCGA patient cohorts, LIN7A mutation is significantly associated with the RNA expression of many other genes, with 2,272 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIN7A-associated genes across cancer lineages are HIGD1AP9, UQCRC1, and MAP2K2. Each is linked with LIN7A in more than 2 cancer types. Because this analysis shows association rather than direction, both LIN7A-to-partner and partner-to-LIN7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIGD1AP9 grouped by LIN7A-low versus LIN7A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN7A→partner) and Y-score (partner→LIN7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HIGD1AP9 →	+0.094	+1.825	<.001	.006	3	3
SKCM	UQCRC1 →	+0.403	+2.093	.001	.003	3	2
SKCM	MAP2K2 →	+0.335	+2.144	.006	.003	3	2
SKCM	KLF16 →	+0.491	+3.347	.001	.004	3	2
SKCM	AGAP3 →	+0.480	+3.604	.002	.001	3	2
SKCM	SMYD5 →	+0.306	+2.757	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,272 associations by consensus.

HIGD1AP9 by LIN7A expression — SKCM

Explore this box plot interactively →