LIN7A

Across TCGA patient cohorts, LIN7A mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIN7A-associated genes across cancer lineages are FoxM1, PCNA, and VHL. Each is linked with LIN7A in more than 3 cancer types. Because this analysis shows association rather than direction, both LIN7A-to-partner and partner-to-LIN7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by LIN7A-low versus LIN7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN7A→partner) and Y-score (partner→LIN7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.200	+1.584	.021	.009	3	4
UCEC	PCNA →	+0.231	+1.584	.001	.009	3	3
UCEC	VHL →	-0.940	-2.169	<.001	.003	3	3
UCEC	Cyclin-E2 →	+0.138	+1.425	.014	.027	3	3
UCEC	eIF4G →	+0.253	+1.321	.015	.029	3	2
UCEC	JNK_pT183_Y185 →	-0.174	-2.087	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

FoxM1 by LIN7A expression — UCEC

Explore this box plot interactively →