LIN7A

Across TCGA cell cohorts, LIN7A mutation is significantly associated with the RNA expression of many other genes, with 703 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LIN7A-associated genes across cancer lineages are ETFBKMT, ADAM7, and C3orf20. Each is linked with LIN7A in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN7A-to-partner and partner-to-LIN7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETFBKMT grouped by LIN7A-low versus LIN7A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN7A→partner) and Y-score (partner→LIN7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ETFBKMT →	+0.480	+3.364	.002	.002	3	2
LARGE_INTESTINE	ADAM7 →	+0.004	+3.082	<.001	<.001	3	2
SKIN	C3orf20 →	+0.037	+2.777	.007	.006	3	1
SKIN	TBC1D3G →	+0.672	+3.774	<.001	.001	3	1
SKIN	RPGRIP1 →	+0.262	+3.228	<.001	.009	3	1
BLOOD_Leukemia	PRDM14 →	+0.006	+4.705	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 703 associations by consensus.

ETFBKMT by LIN7A expression — LARGE_INTESTINE

Explore this box plot interactively →