Across TCGA pan-cancer cohorts, LIN54 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LIN54 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LIN54 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LIN54 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where LIN54 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	1.000	0.177	.036	7	view →
PDAC	OS	Median	III,IV	0.991	0.561	.013	3	view →
GBM	DFS	Median	All	0.796	0.566	.040	2	view →
HNSC	OS	Median	All	1.000	0.961	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: LIN54 tumor-vs-normal RNA expression · all LIN54 data types