Across TCGA patient cohorts, LIN54 protein abundance is significantly associated with the RNA expression of many other genes, with 6,863 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LIN54-associated genes across cancer lineages are CENPI, TMEM97, and NEK2. Each is linked with LIN54 in more than 4 cancer types. Because this analysis shows association rather than direction, both LIN54-to-partner and partner-to-LIN54 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN54→partner) and Y-score (partner→LIN54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CENPI →	+0.782	+0.256	<.001	<.001	3	5
LSCC	TMEM97 →	+1.364	+0.258	<.001	<.001	3	5
UCEC	NEK2 →	+1.039	+0.165	<.001	<.001	3	5
UCEC	CENPF →	+1.206	+0.201	<.001	<.001	3	5
BRCA	KIF14 →	+1.033	+0.365	<.001	<.001	3	5
GBM	HELLS →	+1.137	+0.330	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,863 associations by consensus.

Exploration

LIN54 survival (RNA) · tumor vs normal (RNA) · all LIN54 data types