Across TCGA patient cohorts, LIN54 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIN54-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with LIN54 in more than 2 cancer types. Because this analysis shows association rather than direction, both LIN54-to-partner and partner-to-LIN54 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN54→partner) and Y-score (partner→LIN54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.572	-3.794	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.509	+2.019	.011	.005	3	2
UCEC	14-3-3_beta →	-0.108	-3.880	.001	<.001	3	1
UCEC	eEF2 →	+0.367	+2.584	.002	.010	3	1
UCEC	EGFR_pY1068 →	-0.274	-1.807	.001	.004	3	1
UCEC	EGFR →	-0.172	-2.196	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

LIN54 survival (RNA) · tumor vs normal (RNA) · all LIN54 data types