Across TCGA cell cohorts, LIN54 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LIN54-associated genes across cancer lineages are E2F5, OR4F4, and C9orf153. Each is linked with LIN54 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN54-to-partner and partner-to-LIN54 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN54→partner) and Y-score (partner→LIN54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	E2F5 →	+0.709	+3.064	.001	.009	3	1
LARGE_INTESTINE	OR4F4 →	+0.015	+3.009	<.001	.001	3	1
LARGE_INTESTINE	C9orf153 →	+0.228	+3.719	<.001	.001	3	1
LARGE_INTESTINE	DAZ4 →	+0.109	+2.977	.008	.006	3	1
LARGE_INTESTINE	DAZ2 →	+0.113	+3.415	.008	.001	3	1
LARGE_INTESTINE	WDR3 →	+0.724	+3.125	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

LIN54 survival (RNA) · tumor vs normal (RNA) · all LIN54 data types