LIN37

Across TCGA pan-cancer cohorts, LIN37 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LIN37 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LIN37 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LIN37 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

UCEC, OV, and LUAD are the cancer types where LIN37 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.409	1.000	.040	8	view →
OV	DFS	Median	All	0.655	1.000	.011	4	view →
LUAD	OS	Median	III,IV	1.000	0.611	.012	4	view →
GBM	DFS	Median	All	0.784	0.652	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LIN37–UCEC (DFS)

Open the UCEC breakdown →