Across TCGA patient cohorts, LIN28B mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIN28B-associated genes across cancer lineages are eIF4E, FASN, and FoxM1. Each is linked with LIN28B in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN28B-to-partner and partner-to-LIN28B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN28B→partner) and Y-score (partner→LIN28B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.188	+2.201	.007	<.001	3	2
UCEC	FASN →	+0.406	+1.807	.002	.025	3	2
UCEC	FoxM1 →	+0.198	+1.321	.022	.029	3	2
UCEC	Notch1 →	+0.114	+1.594	.015	.021	3	2
UCEC	Snail →	-0.226	-2.807	.034	.002	3	2
UCEC	Cyclin-E2 →	+0.145	+1.584	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Exploration

LIN28B survival (RNA) · tumor vs normal (RNA) · all LIN28B data types