LIMS2

Across TCGA patient cohorts, LIMS2 mutation is significantly associated with the RNA expression of many other genes, with 2,316 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIMS2-associated genes across cancer lineages are MIR2467, PLPP5, and FAM120AOS. Each is linked with LIMS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LIMS2-to-partner and partner-to-LIMS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR2467 grouped by LIMS2-low versus LIMS2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMS2→partner) and Y-score (partner→LIMS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR2467 →	+0.647	+4.260	<.001	.003	3	3
UCEC	PLPP5 →	+0.414	+3.592	.008	.001	3	2
UCEC	FAM120AOS →	+0.398	+2.641	.005	.005	3	2
UCEC	RP9P →	+0.576	+2.329	<.001	.003	3	2
UCEC	SNX25P1 →	+0.358	+3.191	.009	.009	3	2
UCEC	SBF2-AS1 →	+0.446	+2.386	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,316 associations by consensus.

MIR2467 by LIMS2 expression — HNSC

Explore this box plot interactively →