LIMS2

Across TCGA patient cohorts, LIMS2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIMS2-associated genes across cancer lineages are ATM, CD31, and FoxM1. Each is linked with LIMS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both LIMS2-to-partner and partner-to-LIMS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by LIMS2-low versus LIMS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMS2→partner) and Y-score (partner→LIMS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.503	-2.308	.009	.033	3	4
UCEC	CD31 →	-0.165	-2.449	.008	.019	3	3
UCEC	FoxM1 →	+0.219	+2.222	.046	.011	3	2
UCEC	Akt_pT308 →	+0.570	+2.999	.033	.035	3	2
UCEC	P-Cadherin →	-0.145	-2.459	.018	.018	3	2
UCEC	SF2 →	-0.106	-2.209	.022	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ATM by LIMS2 expression — UCEC

Explore this box plot interactively →