LIMS2

Across TCGA cell cohorts, LIMS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,901 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LIMS2-associated GO terms across cancer lineages are Positive regulation of stress fiber assembly, Cell division, and Regulation of cell-substrate adhesion. Each is linked with LIMS2 in more than 10 cancer types. Because this analysis shows association rather than direction, both LIMS2-to-partner and partner-to-LIMS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of stress fiber assembly grouped by LIMS2-low versus LIMS2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMS2→partner) and Y-score (partner→LIMS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of stress fiber assembly →	+0.166	+2.187	<.001	<.001	3	11
BREAST	Cell division →	+0.062	+1.280	<.001	<.001	3	11
BONE	Regulation of cell-substrate adhesion →	+0.126	+2.048	<.001	<.001	3	11
BREAST	Positive regulation of cell-substrate adhesion →	+0.124	+1.999	<.001	<.001	3	10
BONE	Regulation of focal adhesion assembly →	+0.180	+2.224	<.001	<.001	3	10
LIVER	Protein activation cascade →	+0.397	+2.558	.006	.008	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,901 associations by consensus.

Positive regulation of stress fiber assembly by LIMS2 expression — BONE

Explore this box plot interactively →