LIMS1

Across TCGA pan-cancer cohorts, LIMS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LIMS1 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LIMS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LIMS1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

HNSC, LSCC, and GBM are the cancer types where LIMS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.539	0.775	.017	14	view →
LSCC	OS	Quartile	II,III,IV	0.699	1.000	.010	13	view →
GBM	OS	Median	All	0.731	0.951	.001	4	view →
CCRCC	OS	Median	All	1.000	0.683	.021	3	view →
LUAD	DFS	Quartile	III,IV	0.338	0.799	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LIMS1–HNSC (DFS)

Open the HNSC breakdown →