LIMS1

Across TCGA patient cohorts, LIMS1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIMS1-associated genes across cancer lineages are eIF4E, PDK1_pS241, and PDK1. Each is linked with LIMS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIMS1-to-partner and partner-to-LIMS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LIMS1-low versus LIMS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMS1→partner) and Y-score (partner→LIMS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.219	+2.459	.031	.020	3	1
UCEC	PDK1_pS241 →	+0.237	+2.472	.004	.011	3	1
UCEC	PDK1 →	+0.144	+3.013	.005	.018	3	1
UCEC	Tuberin →	+0.445	+2.459	<.001	.020	3	1
UCEC	Cyclin-B1 →	+0.668	+2.459	.013	.020	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

eIF4E by LIMS1 expression — UCEC

Explore this box plot interactively →