LIMS1

Across TCGA cell cohorts, LIMS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,878 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LIMS1-associated GO terms across cancer lineages are Negative regulation of protein-containing complex disassembly, Phosphatidylinositol metabolic process, and Positive regulation of integrin-mediated signaling pathway. Each is linked with LIMS1 in more than 10 cancer types. Because this analysis shows association rather than direction, both LIMS1-to-partner and partner-to-LIMS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein-containing complex disassembly grouped by LIMS1-low versus LIMS1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMS1→partner) and Y-score (partner→LIMS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of protein-containing complex disassembly →	+0.106	+1.503	<.001	<.001	3	11
BONE	Phosphatidylinositol metabolic process →	+0.048	+0.762	<.001	.003	3	11
STOMACH	Positive regulation of integrin-mediated signaling pathway →	+0.248	+1.383	<.001	<.001	3	10
LIVER	Regulation of protein polymerization →	+0.056	+0.958	.003	.002	3	10
BONE	Negative regulation of Rho protein signal transduction →	+0.173	+1.045	<.001	<.001	3	10
SOFT_TISSUE	Cellular response to environmental stimulus →	+0.038	+1.327	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,878 associations by consensus.

Negative regulation of protein-containing complex disassembly by LIMS1 expression — KIDNEY

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