LIMK2

Across TCGA pan-cancer cohorts, LIMK2 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LIMK2 data layer compared with 15 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LIMK2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated LIMK2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, OV, and BLCA are the cancer types where LIMK2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.970	0.607	.003	34	view →
OV	OS	Median	IV	0.028	0.759	.002	30	view →
BLCA	OS	Median	II,III,IV	1.000	0.413	.029	20	view →
LUAD	OS	Median	All	0.323	0.834	.003	12	view →
HNSC	OS	Median	All	0.191	0.710	.021	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LIMK2–UCEC (DFS)

Open the UCEC breakdown →