LIMK2

Across TCGA patient cohorts, LIMK2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIMK2-associated genes across cancer lineages are eIF4E, ACC1, and ARID1A. Each is linked with LIMK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIMK2-to-partner and partner-to-LIMK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LIMK2-low versus LIMK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMK2→partner) and Y-score (partner→LIMK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.229	+2.643	<.001	<.001	3	2
UCEC	ACC1 →	+0.307	+2.013	.010	.016	3	2
UCEC	ARID1A →	-0.149	-3.459	.013	.004	3	2
UCEC	STAT3_pY705 →	-0.318	-2.999	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.485	+1.604	.013	.021	3	2
UCEC	Ku80 →	+0.155	+1.165	.046	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eIF4E by LIMK2 expression — UCEC

Explore this box plot interactively →