LIMK1

Across TCGA patient cohorts, LIMK1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIMK1-associated genes across cancer lineages are eIF4E, PDCD4, and Caspase-7-cleavedD198. Each is linked with LIMK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIMK1-to-partner and partner-to-LIMK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LIMK1-low versus LIMK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMK1→partner) and Y-score (partner→LIMK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.177	+2.472	.010	.010	3	2
UCEC	PDCD4 →	-0.468	-1.990	.002	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.737	+2.189	<.001	.001	3	2
UCEC	A-Raf_pS299 →	-0.102	-1.678	.009	.021	3	1
UCEC	ERK2 →	+0.213	+2.584	<.001	.001	3	1
UCEC	JNK2 →	+0.211	+1.652	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by LIMK1 expression — UCEC

Explore this box plot interactively →