LIMK1

Across TCGA cell cohorts, LIMK1 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LIMK1-associated genes across cancer lineages are XAGE5, OR10D3, and ZNF716. Each is linked with LIMK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIMK1-to-partner and partner-to-LIMK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by LIMK1-low versus LIMK1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMK1→partner) and Y-score (partner→LIMK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	XAGE5 →	+0.534	+4.643	<.001	.005	3	2
BLOOD_Lymphoma	OR10D3 →	+0.023	+4.643	.001	.005	3	2
LUNG_NSCLC_LUAD	ZNF716 →	+0.356	+2.882	.003	.009	3	2
LUNG_NSCLC_LUAD	ZNF729 →	+0.346	+2.896	<.001	.008	3	2
BLOOD_Lymphoma	NEUROD4 →	+0.156	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	PLCZ1 →	+0.127	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

XAGE5 by LIMK1 expression — BLOOD_Lymphoma

Explore this box plot interactively →