Across TCGA patient cohorts, LIME1 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIME1-associated genes across cancer lineages are IGKV2OR2-2, MIR6508, and IGKV3-31. Each is linked with LIME1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIME1-to-partner and partner-to-LIME1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIME1→partner) and Y-score (partner→LIME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGKV2OR2-2 →	+0.190	+4.344	.005	.002	3	1
UCEC	MIR6508 →	+0.697	+4.430	<.001	.002	3	1
SKCM	IGKV3-31 →	+0.307	+5.292	<.001	.006	3	1
SKCM	IGHVIII-26-1 →	+0.212	+6.797	<.001	<.001	3	1
SKCM	IGLVV-58 →	+0.319	+5.159	<.001	.007	3	1
SKCM	MTND5P21 →	+0.087	+5.594	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

LIME1 survival (RNA) · tumor vs normal (RNA) · all LIME1 data types