LIMCH1

Across TCGA patient cohorts, LIMCH1 mutation is significantly associated with the RNA expression of many other genes, with 4,664 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIMCH1-associated genes across cancer lineages are C16orf91, RNF126, and POLRMT. Each is linked with LIMCH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LIMCH1-to-partner and partner-to-LIMCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf91 grouped by LIMCH1-low versus LIMCH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMCH1→partner) and Y-score (partner→LIMCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C16orf91 →	+0.441	+1.721	<.001	<.001	3	3
UCEC	RNF126 →	+0.446	+1.894	<.001	<.001	3	3
UCEC	POLRMT →	+0.335	+1.423	<.001	<.001	3	3
LGG	CHCHD3P2 →	+0.092	+5.679	<.001	.003	3	3
SKCM	GAS2L1 →	+0.414	+1.636	.001	.008	3	3
UCEC	PRAC2 →	-1.053	-1.689	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,664 associations by consensus.

C16orf91 by LIMCH1 expression — UCEC

Explore this box plot interactively →