LIMCH1

Across TCGA patient cohorts, LIMCH1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIMCH1-associated genes across cancer lineages are HER3, p27_pT157, and ATM. Each is linked with LIMCH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LIMCH1-to-partner and partner-to-LIMCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by LIMCH1-low versus LIMCH1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMCH1→partner) and Y-score (partner→LIMCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER3 →	+0.294	+1.678	.022	.020	3	3
SKCM	p27_pT157 →	+0.109	+1.395	.001	.049	3	3
UCEC	ATM →	-0.435	-2.156	<.001	.002	3	3
LUSC	p53 →	-0.531	-3.160	.001	.019	3	2
UCEC	Annexin-1 →	+0.669	+3.000	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.212	-1.584	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

HER3 by LIMCH1 expression — SKCM

Explore this box plot interactively →