LIMA1

Across TCGA patient cohorts, LIMA1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIMA1-associated genes across cancer lineages are eIF4E, ATM, and Tuberin. Each is linked with LIMA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LIMA1-to-partner and partner-to-LIMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LIMA1-low versus LIMA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMA1→partner) and Y-score (partner→LIMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.207	+2.459	.004	<.001	3	3
UCEC	ATM →	-0.351	-1.736	.025	.007	3	3
UCEC	Tuberin →	+0.317	+2.700	<.001	.005	3	2
UCEC	c-Kit →	-0.224	-2.459	.005	<.001	3	2
UCEC	ERK2 →	+0.206	+2.906	.001	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.143	-2.087	.014	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by LIMA1 expression — UCEC

Explore this box plot interactively →