LIMA1

Across TCGA cell cohorts, LIMA1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LIMA1-associated genes across cancer lineages are MAGEB5, FABP9, and OR56A5. Each is linked with LIMA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIMA1-to-partner and partner-to-LIMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by LIMA1-low versus LIMA1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMA1→partner) and Y-score (partner→LIMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	FABP9 →	+0.093	+4.643	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	SCYGR10 →	+0.180	+5.357	<.001	.003	3	1
LARGE_INTESTINE	SH3GL2 →	+1.613	+3.252	<.001	.009	3	1
LARGE_INTESTINE	CPO →	+0.103	+3.514	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MAGEB5 by LIMA1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →