LIMA1

Across TCGA cell cohorts, LIMA1 mutation is significantly associated with the mutation status of many other genes, with 4,815 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LIMA1-associated genes across cancer lineages are ITGB4, RAPGEF6, and TMEM63B. Each is linked with LIMA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LIMA1-to-partner and partner-to-LIMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGB4 grouped by LIMA1-low versus LIMA1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMA1→partner) and Y-score (partner→LIMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ITGB4 →	+4.297	+4.857	.009	.009	1	5
BREAST	RAPGEF6 →	+4.297	+4.857	.009	.009	1	4
BLOOD_Leukemia	TMEM63B →	+4.894	+5.870	<.001	<.001	1	4
LUNG_NSCLC_LUSC	UTRN →	+4.228	+4.228	.004	.004	1	4
LUNG_NSCLC_LUSC	DDX60L →	+4.228	+4.228	.004	.004	1	4
LUNG_NSCLC_LUSC	MYH7 →	+4.228	+4.228	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,815 associations by consensus.

ITGB4 by LIMA1 expression — BREAST

Explore this box plot interactively →