Across TCGA cell cohorts, LILRB4 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LILRB4-associated genes across cancer lineages are GPR42, IL25, and OR6C2. Each is linked with LILRB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LILRB4-to-partner and partner-to-LILRB4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LILRB4→partner) and Y-score (partner→LILRB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GPR42 →	+0.013	+4.736	<.001	.009	3	1
LARGE_INTESTINE	IL25 →	+0.075	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR6C2 →	+0.202	+5.415	<.001	.004	3	1
LARGE_INTESTINE	DBX2 →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GFRAL →	+0.006	+5.415	.007	.004	3	1
LARGE_INTESTINE	FOXB2 →	+0.033	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

LILRB4 survival (RNA) · tumor vs normal (RNA) · all LILRB4 data types