LILRB2

Across TCGA patient cohorts, LILRB2 mutation is significantly associated with the RNA expression of many other genes, with 3,826 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LILRB2-associated genes across cancer lineages are CDC45, FANCA, and PRC1. Each is linked with LILRB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both LILRB2-to-partner and partner-to-LILRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC45 grouped by LILRB2-low versus LILRB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LILRB2→partner) and Y-score (partner→LILRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDC45 →	+0.693	+2.584	<.001	<.001	3	5
UCEC	FANCA →	+0.637	+1.893	<.001	<.001	3	4
UCEC	PRC1 →	+0.557	+1.934	.002	.002	3	4
LUAD	FANCG →	+0.506	+2.593	<.001	.006	3	4
LUAD	EME1 →	+0.731	+2.757	<.001	.002	3	4
LUAD	FANCC →	+0.550	+2.596	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,826 associations by consensus.

CDC45 by LILRB2 expression — UCEC

Explore this box plot interactively →