LILRB2

Across TCGA patient cohorts, LILRB2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LILRB2-associated genes across cancer lineages are Notch1, Cyclin-B1, and Transglutaminase. Each is linked with LILRB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LILRB2-to-partner and partner-to-LILRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by LILRB2-low versus LILRB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LILRB2→partner) and Y-score (partner→LILRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.148	+2.009	.001	.005	3	3
UCEC	Cyclin-B1 →	+0.628	+2.415	<.001	.002	3	3
LUAD	Transglutaminase →	-0.322	-3.000	.028	.034	3	2
SKCM	MYH11 →	-0.659	-1.584	.036	.032	3	2
UCEC	Stathmin →	+0.128	+2.087	.004	.005	3	2
UCEC	TFRC →	+0.729	+2.643	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Notch1 by LILRB2 expression — UCEC

Explore this box plot interactively →