LILRB2

Across TCGA cell cohorts, LILRB2 mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible LILRB2-associated genes across cancer lineages are APOC4, TAS1R2, and MAGEB4. Each is linked with LILRB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LILRB2-to-partner and partner-to-LILRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOC4 grouped by LILRB2-low versus LILRB2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LILRB2→partner) and Y-score (partner→LILRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APOC4 →	+0.196	+3.759	<.001	.004	3	2
LUNG_NSCLC_LUAD	TAS1R2 →	+0.008	+4.019	<.001	<.001	3	2
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	2
LARGE_INTESTINE	ZAN →	+0.011	+2.560	<.001	.008	3	2
SKIN	TSPYL6 →	+0.041	+3.793	<.001	.007	3	2
SKIN	KRTAP6-1 →	+0.060	+4.437	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

APOC4 by LILRB2 expression — BLOOD_Leukemia

Explore this box plot interactively →